WSURF Case 417
Methods for Detection of Transmissible Spongiform Encephalopathies
Summary
Transmissible spongiform encephalopathies (TSEs, also known as prion diseases) are a group of progressive conditions that affect the brain and nervous system of humans and animals and are transmitted by prions. Mental and physical abilities deteriorate and myriad tiny holes appear in the cortex causing it to appear like a sponge (hence 'spongiform') when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including problems with movement that worsen over time.
The invention involves a non-invasive method of detecting a specific protein that indicates the presence of TSE in ruminant animals. The invention uses monoclonal antibodies that bind to a prion protein in animal tissue from sheep, cattle, mule, deer and elk. The invention comprises a non-invasive diagnostic assay using third eyelid lymphoid tissue to detect prion protein in sheep. The invention is a specific, reliable and flexible tool to accurately diagnose TSE. This method is a practical and inexpensive way to test for presence of this potentially fatal neurological disease.
Applications & Advantages
IP Status
The technology is protected by two US patents; 6,165,784 & 6,514,707 , and is available for license on a non-exclusive basis.
For more information about this technology please contact WSURF:
1610 NE Eastgate Blvd, Suite 650
Pullman, WA 99164
Phone: (509) 335-5526
Fax: (509) 335-7237
wsurf@wsu.edu
