WSURF Case 611
Non-Transformed Sertoli Cell Lines for Transplantation, Functional Genomics and Drug Discovery
Summary
Currently primary preparations of Sertoli cells are used for two major biomedical research applications.
Sertoli cells are used for transplantation experiments to test neuro-degenerative disease and prevent tissue rejection during organ transplantation (e.g. islets).
Transformed Sertoli lines have problems with developing tumors and primary cells are not practical for product development. The development of adult non-transformed Sertoli cell-lines is a significant advance for this biomedical application of Sertoli cell transplantation.
Sertoli cells are also used in functional genomic assays for drug discovery.
The Sertoli cell is a target for a number of male reproductive endocrinology pharmaceuticals such as contraceptives and fertility agents. The use of primary cell-lines has limitations for product development. The use of transformed cell lines can provide anomalous results irrelevant of Sertoli cells. The availability of non-transformed cell lines would provide a major advance in drug discovery and functional genomics of Sertoli cell targeted pharmaceuticals.
Applications & Advantages
- Transplantation experiments to test neuro-degenerative disease and prevent tissue rejection during organ transplantation (e.g. islets)
- Functional genomic assays for drug discovery
- Development of non-transformed celllines from other types of cells using a similar strategy
IP Status
US Patent pending. Exclusive US rights available.
For more information about this technology please contact WSURF:
1610 NE Eastgate Blvd, Suite 650
Pullman, WA 99164
Phone: (509) 335-5526
Fax: (509) 335-7237
wsurf@wsu.edu
