WSURF Case 657
Foldamer Polymers as Probes
Summary
This technology utilizes novel probes to detect and identify target biomolecules in a sample. These probes employ conformational changes induced by molecular recognition events to initiate changes in the optical properties of the probe (e.g. the modulation of a fluorescence or absorption response upon target binding). Methods, including solid phase synthesis techniques for making probe molecules have been developed.
Applications & Advantages
- Versatile approach to molecular recognition
- Hairpin formation not a prerequisite for self association
- Optical response can be tailored to application
- Multiple targets can be probed simultaneously
- Both the composition and nature of the probes and reporters can be modulated
IP Status
This technology is protected by a published US patent application . Exclusive US rights are available.
Publications
Han, Jason J.; Wang, Wei; Li, Alexander D. Q.. Folding and Unfolding of Chromophoric Foldamers Show Unusual Colorful Single Molecule Spectral Dynamics. Journal of the American Chemical Society (2006), 128(3), 672-673.
Wang, Wei; Wan, Wei; Stachiw, Andrew; Li, Alexander D. Q.. Foldamers with Hybrid Biological and Synthetic Sequences as Selective DNA Fluorescent Probes. Biochemistry (2005), 44(32), 10751-10756.
Wang, Wei; Wan, Wei; Zhou, Hong-Hui; Niu, Shuqiang; Li, Alexander D. Q..  Alternating DNA and ï° -conjugated sequences. Thermophilic foldable polymers.   Journal of the American Chemical Society (2003), 125(18), 5248-5249.
Wang, Wei; Li, Lin-Song; Helms, Greg; Zhou, Hong-Hui; Li, Alexander D. Q.. To Fold or to Assemble? Journal of the American Chemical Society (2003), 125(5), 1120-1121.
