WSURF Case 781
Dual Gate IMS for Coupling to Slow Transit Time Instruments
Summary
Traditionally ion mobility spectrometry (IMS) has been used for the analysis of gas phase compounds, however with the advent of ESI and MALDI the technique's scope of analysis has greatly expanded. The powerful prospects of combining IMS and mass spectrometry (IMMS) to yield instruments capable distinguishing ions based upon both size and mass to charge ratios has led to a large body of work directed at the development of IMMS instruments. While many low pressure (1-100 Torr) IMMS systems have been realized only a limited number of high pressure systems have been developed. Moreover, those which have been described suffer from limitations in the fragmentation information available from such systems.
WSU Researchers have developed an approach to selectively filter and subsequently analyze ion pulses originating from an atmospheric pressure IMS system. These developments enable applications such as IMS-QITMS, IMS-FTMS, IMS-FAIMS & IMS-FAIMS-MS
Applications & Advantages
- Many prototype instruments are developed
- Allows for nD analysis of low abundance species
- Sensitive
- Adaptable
IP Status
The technology is protected by a US patent application and is available for exclusive licensing.
Publications
Clowers, Brian H.; Hill, Herbert H., Jr.. Mass Analysis of Mobility-Selected Ion Populations Using Dual Gate, Ion Mobility, Quadrupole Ion Trap Mass Spectrometry. Analytical Chemistry (2005), 77(18), 5877-5885
For more information about this technology please contact WSURF:
1610 NE Eastgate Blvd, Suite 650
Pullman, WA 99164
Phone: (509) 335-5526
Fax: (509) 335-7237
wsurf@wsu.edu
